Peptide transporters are characterized by the ability to transport a range in different types of peptides and their derivatives across membranes in an energy-dependent manner (Lubkowitz et al. [1997]; Lubkowitz et al. [1998]).
The SIPRI report shows how air cargo carriers involved in humanitarian aid and peacekeeping operations have also transported a range of other conflict-sensitive goods such as cocaine, diamonds, coltan and other precious minerals.
The PTS is promiscuous and will transport a range of polyamine-based molecules.
P-gp is able to transport a range of molecules, including amphipathic drug compounds, chemotherapy agents (such as doxorubicin), lipid, steroids, and peptides.
It has been reported that MCT2 and MCT4 have the potential to transport a range of monocarboxylates (Halestrap and Price, 1999).
Human MRP4 (and MRP5) have the ability to transport a range of endogenous molecules involved in cellular signaling, like cyclic nucleotides, eicosanoids and conjugated steroid hormones [ 19].
Mrs2 mediates high capacity Mg2+ influx in isolated yeast mitochondria driven by the inner membrane potential but also transports a range of divalent cations such as Ni2+, Co2+, and Cu2+ [ 6].
Functional properties of MCT2 and MCT4 as elucidated by expression in Xenopus oocytes have indicated that these MCT isoforms are able to transport a range of monocarboxylates (Halestrap and Price, 1999).
We previously showed that PepTSt displays broad specificity for dipeptides, being able to transport a range of charged and hydrophobic peptides with IC50 values in the region of 5 400 μM [ 3].
The observations discussed suggest that S. pseudintermedius may use the highly conserved SitA metal-binding residues to capture and transport a range of nutrients, likely with a preference for Mn2+ ions for which it displayed the canonical commonly observed geometry and bond lengths [ 49, 50].
