Sentence examples for transporter without from inspiring English sources
The substitutions of crucial Lys into Met in the nucleotide binding domains (NBD) carried by MM (position 939 and 1952) are known to lead to a complete loss of function of the ABCA1 transporter without affecting its trafficking.
Lmo0859 Lmo0861 are annotated in both ListiList and the ABCdb database of ABC transporters [35] as components of a sugar ABC transporter without a particular specificity, hence they were indeed suitable candidates for the uptake of maltose.
These data suggest that PD173074 blocks the function of the transporter without affecting its expression levels.
The group VII bacteriocin gene clusters contain a unique ABC transporter gene, which appears to be a fusion of a short and long type ABC transporter without the C39 peptidase domain in the long type.
Indeed, the Km value of rOCT3-mediated CTN transport (47.7 mM) [ 51] is still much higher than the CTN concentration in the CSF of patients with renal failure (168-521 μM [ 85]), suggesting that rOCT3 functions as a CTN transporter without saturation.
Moreover, we showed that CUDC-101 modulated the function of both transporters without affecting the protein expression of either ABCB1 or ABCG2.
E. coli can take up ferrous iron with the Feo and Efe transporters without the involvement of citrate [ 25].
Furthermore, it was showed that curcumin modulated the drug efflux of yeast ABC transporters without affecting the levels of transcription genes encoding these transporters.
Injection of low-dose LPS (1, 5 mg/kg) also led to renal dysfunction paralleled by a downregulation of renal urea transporters without alterations in blood pressure.
On the other hand, the HS2 family had a decreased abundance of uptake transporters without alterations in the abundance of Ireg1.
One approach that has been used to overcome MDR in cancer cells is to find or synthesize compounds that can block the efflux action of the ABC transporters without producing significant toxic effects [ 31].
