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We showed that by changing one amino acid, E457, in hSGLT3 for the amino acid present in hSGLT1, Q457, we converted this sugar sensor into a sugar transporter with the same stoichiometry as hSGLT1.
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When the B. subtilis BceB loop was replaced by loops from subfamily IV ABC transporters with the same specificity, none of the heterologous ABC transporter loops was found to restore bacitracin resistance to this bacterium.
The PN11-14 exposure had much smaller effects on receptors but still elicited transporter suppression with the same regional and sex selectivity.
The ability of CINs to mediate glutamatergic transmission is consistent with reports that these cells express the vesicular glutamate transporter VGluT3, which co-localizes with the vesicular ACh transporter in the same presynaptic terminals [6], [7], [9].
All journeys were made at the same starting time (8 00 h) and with the same transporter, transport conditions and driver.
This protein is a small E.coli multidrug transporter belonging to the same drug/metabolite transporter family described above that acts by exchanging various positively charged aromatic drugs across the plasma membrane with protons.
Down-regulation of the argR (-1.57-fold) gencodesich encodes the transcriptional repressor of the arginine transporter, occurred at the same time as with the up-regulation of the arginine transporter artIQM/ artJ.
Moreover, the results obtained with genes corresponding to transporter activity on GO (hexose transporter-like protein (ht) and zinc-regulated transporter (zt)) demonstrated the same time-course expression profiles as the genes that present binding activity (Table 2 and Additional file 1).
Different drugs can interact differently with the same ABC transporter, both structurally (having different binding sites [55]) and thermodynamically (causing different interactions with the rate-limiting transition state [56]).
Although it remains unclear if the protein kinase genes associated with module 6 directly and/or indirectly regulate the transporters via the phosphorylation machinery, the coexistence of many protein kinases and transporter genes in the same coexpression module provides new insights into the nutrient usage mechanism under nutrient deprivation conditions.
CA IV is expressed both in the kidneys and lungs [ 61] and similarly to CA II, CA IV can interact with the same aforementioned transporters that span the renal cell surface [ 62].
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CEO of Professional Science Editing for Scientists @ prosciediting.com