Sentence examples for transporter value from inspiring English sources

The R transporter value may also be predicted using experimentally determined protein expression levels, but would be only slightly less than the value estimated from mRNA data.

Additionally, liver cirrhosis has a pronounced impact on the observed pharmacokinetics of some compounds (e.g., valsartan) but not others (e.g., olmesartan), which makes it challenging to use a unique R transporter value to describe the change in the pharmacokinetics of all the compounds.

To test this hypothesis, we assumed that there are type-1 and type-2 uptake transporters responsible for the hepatic uptake of these compounds that have different R transporter values, and estimated parameters by fitting the clinical observations.

Assuming liver cirrhosis has a similar impact on all uptake transporters, R transporter values of CP-A and CP-B are estimated by fitting observed concentration time courses of patients while fixing other parameters at their mean values in Table 3 (Method 2).

The current studies describe the in vitro profile of SB-649915 (6-[ 1-{2-[ 2-methylquinolin-5-yl)oxy]ethyl}piperidin-4-yl)methyl]-2H-1,4-benzoxazin-3(4H)-one), a novel compound which has high affinity for human recombinant 5-HT1A, 5-HT1B and 5-HT1D receptors (pKi values of 8.6-[ 1-{2-[ 2-methylquinolin-5-ylhe human recombinant 5-HT transporter (pKi value of 9.3).

In the brainstem, diazinon reduced transporter binding values, but only when the dose was raised above the threshold for cholinesterase inhibition; in contrast, values were elevated in the forebrain even at low doses.

Based on the original HMMER2 results, the distinction among the sugar transporters (E-values between 1.28e 3 and 8.31e 2), the proton transporters (E-values between 8.25e 3 and 7.88e 2) and the peptide/amino-acid transporters (E-values between 1.18e 2 and 3.73e 2) would have been difficult due to the highly overlapping ranges.

SB-649915 also displays high affinity for rat, guinea pig, mouse and marmoset native tissue 5-HT1A, 5-HT1B and 5-HT1D receptors and rat native tissue 5-HT transporters (pKi values ≥ 7.5).

Km is defined as the transporter's specific value of glycemia for which 50% of transport capacities are reached.

For TC1 under molecular function category hydrolase activity (p-value: 0.0101) and ion transmembrane transporter activity (p-value: 0.0328) was found to be enriched.

Two classes were found to be significantly correlated with unstable promoter regions (Wilcox rank test): the transporter class (p-value = 0.03) and the regulator class (p-value = 2 10-4).