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In addition, in treatments in this study where there was higher concentrations of nitrate (>2.5 μM), the transporter set MAE14790, 14780, 14770 had much higher fold change values (between 4.56 and 23.18) than MAE18880, 18890, 18900 (between 2.59 and 4.16).
To avoid a bias of the enrichment test due to the transporters reactions, the latter were not considered for the test and therefore the population size N was defined as the number gene regulated reactions in macrophage being not part of the transporter set.
Fangio and Moss had built up a substantial lead when, aware of the potential public-relations disaster only 10 years after the end of a war in which Germany had occupied France, the Mercedes team quietly withdrew in the middle of the night, loading the remaining cars on to their transporters and setting off on the 500-mile drive back to Stuttgart.
As administrators in major hospitals around the country know well, a dawdling patient transporter can set off a chain reaction of delays throughout the institution.
Similarly, a nitrate/nitrite transporter gene set (nrtBCD) was upregulated by 0.95 ± 0.24 log2 fold change during days 2 5 but increased by three-fold to 2.62 ± 0.07 log2 fold change on day 6 after nitrate was added (Fig. 6b).
Moreover, the density of the co-transporter necessary for setting the chloride equilibrium potential in the medulla increases significantly during the post-natal period (Liu and Wong-Riley, 2012).
We use five systems, viz., leucine transporter (LeuT), galactose transporter (vSGLT), glutamate transporter (GlT), glycerol 3-phosphate transporter (GlpT), and an ATP-binding cassette transporter (ABCT); this set samples mechanistically diverse classes of primary and secondary active transporters, the latter including symporters and an antiporter.
Within the model, the second transporter was removed by setting its maximal activity (αH, αL) equal to zero.
The calculation is repeated with setting the transporter reaction flux rate v a of the amino acid of interest to zero, yielding the precursor metabolite uptake fluxes v p a →0 for the altered constraint.
