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To further test the transporter role for myosin-Va, we investigated the activity of lever-arm truncation mutants that have reduced step size and velocity in the melan-d1 complementation assay [ 21, 22].
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The C-terminus of the biogenic amine transporter plays a critical role in the regulation of transporter function and intracellular trafficking [5] [15].
Others genes showing expansion and diversification in A. euteiches comprise ABC transporters whose role in mediating resistance to plant toxins and fungicide has been suggested in Phytophthora [70].
30% of the conserved staphylococcal lipoproteins are substrate-binding proteins of ABC transporters with roles in nutrient transport.
Three CUT1 transporters with a role in transport of hemicellulose/pectic polymer degradation products have been described and functionally characterized in G. stearothermophilus T-6.
These reports all support the idea that Zn is an intracellular signaling molecule and lead to the prediction that Zn transporters have roles not only for maintaining Zn homeostasis, but also for mediating intracellular signaling events [5].
In insects, it has been shown that ABC transporters have roles in uric acid metabolism, development and possibly in insecticide resistance [ 10].
While the literature suggests that VGB has interactions with other transporters, the roles of these transporters in the context of the brain are poorly understood and are outside the scope of the present article.
The endogenous function of the family of HKT transporters and their role in Na+ transport and provision of salinity tolerance to plants has been reviewed recently [8].
Such transporter played a role in absorbing apoplasmic precipitated Fe by secreting phenolics like PCA or caffeic acid.
However, it is unknown whether the anandamide membrane transporter plays a role in this modulation.
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