Sentence examples for transporter interaction from inspiring English sources

For example, Sedykh et al. collected and published a large collection of transporter interaction data for small molecules focused on major human intestinal transporters with the aim of building predictive models [29].

Our data suggest that the E457Q substitution changes the transporter interaction with DNJ and renders it more similar to hSGLT1.

Importantly, KP722 induced apoptosis in MDR cells without preferential accumulation or evidence of direct transporter interaction.

We identified a promising pyrazolo[1,5- a]pyrimidine compound devoid of ABC transporter interaction, highly suitable for further preclinical and clinical evaluation for the treatment of cancer.

Assessment of features involved in the ABC transporter substrate specificity from a compound library revealed high polar surface area (>100 Å) as a key determinant of transporter interaction.

We identified unfavourable properties in the pyrazolo[1,5- a]pyrimidine series and, using that information, synthesised a novel orally active CDK inhibitor devoid of ABC transporter interaction that inhibits the growth of solid tumours in mice.

The International Transporter Consortium has established decision trees for investigating the transporter interactions of drugs (International Transporter Consortium et al., 2010).

In this use case we are employing the molecular structure of catechin to search for similar compounds with annotated transporter interactions.

These findings have led to the suggestion that multivalent interactions between HA and CD44 may be necessary for stabilization of transporter interactions within the plasma membrane [ 52].

ML352 exhibited noncompetitive choline uptake inhibition in intact cells and synaptosomes and reduced the apparent density of hemicholinium-3 (HC-3) binding sites in membrane assays, suggesting allosteric transporter interactions.

With respect to the ligand-based method for substrates of OATP1B1, a pharmacophore model was generated with published Km values, and it demonstrated that the key molecular features for substrate transporter interactions appeared to be two hydrogen bond acceptors at either end of a large hydrophobic area.