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In addition, its effects on cell viability and neurotransmitter transporter capacity were examined to evaluate potential cell toxicity mediated by NAX-5055.
The significant upregulation of the transporters showed the more powerful transporter capacity of materials in strain YX-1217 compared to YX-1217G ATCC10151015, which enables YX-1217 to quickly and sufficiently transport substances (macromolecules, small molecules, and ions) into, out of, or within a cell.
Although this low specificity may provide an advantage by enabling the system to cope with "new" chemicals (e.g., environmental pollutants), a disadvantage is that the transporter capacity is more easily saturated in the presence of many substrates, and its protective role can then be lost.
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Predictions could be further improved if more information were available on reaction irreversibilities, transporter capacities, feedback regulations, and nutritional conditions within the different hosts.
Unchanged EAAT2 protein expression as revealed by western blot analysis does not rule out a posttranslational effect of ceftriaxone on the number of functional transporters and the transport capacity of a single transporter protein in the plasma membrane.
Acidification of the apoplast below pH 4.8, would further activate the plant sucrose transporter, but simultaneously reduce the transport capacity of the fungal transporter.
We have previously shown that glucose uptake is the rate limiting step for glycolytic flux in strains expressing a series of individual glucose transporters with reduced transport capacity [ 5].
The Gxf1 transporter had the highest transport capacity and the highest xylose growth rate, followed by the Sut1 transporter.
Among the transporters investigated in this work, the Gxf1 transporter clearly improved the xylose transport capacity and growth rate more than the Sut1 and At5g59250 transporters.
They managed to engineer transporters with improved xylose-transporting capacity and although challenges remain such as the tradeoff between transport efficiency and substrate affinity, or the preference of glucose to xylose, protein engineering seems to be a promising tool to create ideal xylose transporters for lignocellulose biomass conversion.
In this study we demonstrate that tyrosine dimerization in a polytopic transmembrane protein, the zinc transporter 3 (SLC30A3/ZnT3), regulates the transporter's subcellular localization and its transport capacity.
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