Sentence examples for transporter blocking from inspiring English sources

VER is a non-specific inhibitor of ABC transporters and is itself a transport substrate of Pgp and BCRP competing with drugs for the transporter, blocking the efflux of the chemotherapeutic agent.

Cocaine binds tightly to the dopamine transporter, blocking the reuptake of dopamine and enhancing the signals it sends.

Cocaine inhibits the dopamine transporter, blocking a major mechanism of dopamine clearance from the synapse and, thus, resulting in increased levels of extracellular dopamine.

Our data also provide evidence that the postulated MASCO (Tataroglu et al., 2006) represents a long-period manifestation of the DUO as a result of methamphetamine's action on the dopamine transporter, blocking dopamine reuptake thereby increasing extracellular DA levels.

A recent study showed that the association between a CD44 variant and glutamate cystine transporter blocked ROS-induced stress signalling, promoting the proliferation of gastrointestinal CSC, which expressed high levels of CD44 (Ishimoto et al, 2011).

We investigated its ability to increase intracellular creatine levels even after block of creatine transporter, and to counter cell damage induced by transporter block.

Reboxetine, the first selective norepinephrine (noradrenaline) reuptake inhibitor used in the treatment of depression, 1 mainly acts by binding to the norepinephrine transporter and blocking reuptake of extracellular norepinephrine.

In addition, MYC is important for the increased transcription of metabolic enzymes required for anabolism in cancer and fast-growing cells, regulating the conversion of glucose to pyruvate through the activation of important glycolytic genes and glucose transporters, while blocking the entry of pyruvate into the TCA cycle via pyruvate dehydrogenase kinase (PDK1).

One possibility is the development of a ligand for NE for use in positron emission tomography (PET), a novel technique that is currently being used to image serotonin transporter sites blocked by SSRIs.

Hemicholinium 3 partially inhibits PCho/Cho release from TPA-stimulated PNT1A cells, suggesting that Cho release via a CTL1 family transporter is blocked, whereas PCho release is unaffected.

Inhibition of platelet aggregation could only be seen in whole blood when the action of the equilibrative nucleoside transporter was blocked using dipyridamole [ 78].