Sentence examples for transporter blockade from inspiring English sources

These rapid and brain-encompassing connectivity changes linked to acute serotonin transporter blockade suggest a key role for the serotonin transporter in the modulation of the functional macroscale connectome.

This behavior is in sharp contrast to the direction of tonic current change we would expect from a GABA transporter working in the typical, outside-in direction, where the transporter blockade would lead to increased GABA ergic inhibition.

While postnatal ketanserin treatment blocks anxiety behavior in MS animals, it does not influence baseline anxiety in control animals, in striking contrast to studies demonstrating a robust effect on baseline adult anxiety following postnatal 5-HT1A receptor (30) or serotonin transporter blockade (29).

To assess the antipsychotic and pro-cognitive potential of this approach, we examine the strategies designed to enhance glycine-B site occupancy through glycine transporter 1 (GlyT1) blockade.

Martina, M. et al. Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels.

Fluoxetine is a well-known antidepressant of common clinical use that blocks the serotonin transporter (SERT), the blockade of the 5-HT reuptake increasing the 5-HT endogenous levels and potentiating the 5-HT effects at the synaptic cleft [22].

There are no brain-penetrant agents that selectively target glutamate transporters, and pharmacological blockade of single receptors is likely to have limited translational validity when modeling hypoglutamatergic states.

The main effect of cocaine is through the blockade of transporter-mediated dopamine reuptake, leading to an increase in dopamine levels and stimulation of dopamine receptors.

There are relatively low levels of DA transporters in the PFC [ 42]; thus the increase in both DA and NE levels likely occurs through blockade of NE transporters, which are thought to transport both NE and DA in the PFC [ 42].

Selective blockade of the DA transporter (DAT) or the 5-HT transporter (SERT), but not the NE transporter (NET), was sufficient to induce pMeCP2 in the CNS.

Blockade of this transporter decreased the intracellular pools of inositol leading to a concomitant decrease in PIP2 and IP3 that reduces mitochondrial Ca2+ and ATP levels.