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The P AB values of well-transported and poorly transported compounds were > 1 × 10−5 and < 1 × 10−6 cm/s, respectively [16, 17].
First, we predicted that the extent of absorption (i.e., fractional absorption or bioavailability) of the nonactively transported compounds would be inversely related to their molecular weights.
Finally, if the majority of glucose is absorbed passively in great fruit-eating bats, then absorption of 3OMD-glucose will be similar in rate and extent to that of the nonactively transported compounds, after adjustment for differences in molecular size.
This has been observed for other passively transported compounds as well (43).
The reactivity of the UIC2 antibody with Pgp is increased by the addition of Pgp transported compounds.
Other more frequently transported compounds were the branched-chain amino acids which are involved in the biosynthesis of membranes with altered properties (fluidity).
Similar(51)
The results suggest that PBBs stimulate hepatic drug elimination in rats and mice, but the magnitude of the effect is dependent on age and transported compound.
More divergent are the membrane subunits, and least similar are the periplasmic ligand-binding subunits, perhaps understandably divergent as their binding specificities for each transported compound will differ with the properties of the compounds [ 31].
Intensive studies of substrate promiscuity in bacterial transporters and secretion systems will allow for the determination of a set of rules to which a transported compound needs to adhere.
Experiments and molecular docking both showed that human serum albumin (HSA) could effectively transport compound 5d and hydrophobic interactions and hydrogen bonds play important roles in the association of compound 5d with HSA.
The weakly transported heterocyclic compounds stimulate relatively low levels of efflux with isonipecotic acid (Isonip) being more effective than l-pipecolic acid (l-Pip).
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