The neuroprotective functions of WT Htt include inhibition of caspase-3, induction and transport of brain-derived neurotrophic factor (BDNF), and guarding against DNA damage and excitotoxicity [7] [11].
Moreover, Dompierre et al. [5] found that inhibiting HDAC6 reversed the transport deficit in a Huntington's disease model by increasing the vesicular transport of Brain-Derived Neurotrophic Factor (BDNF), another kinesin-1 cargo protein.
Indeed, tubacin ameliorates axonal transport of brain-derived neurotrophic factor (BDNF) in primary striatal neurons from HdhQ109 knock-in mice.
Although the mutant protein is known to form protein aggregates leading to neuronal toxicity, the loss of wild-type (WT) huntingtin functions – which include axonal transport of brain-derived neurotrophic factor (BDNF) – might also play a role in HD.
Some of the potential difficulties in using whole animal KO animals to assess the effects of CP transport on brain parenchyma are exemplified by the effects of such KOs for the ABC transporters.
These different transport proteins of brain mediate the uptake and extrusion of various metabolites and compounds.
Drug that is injected into the CSF compartment is rapidly transported out of brain to the blood.
Accumulation of a-Syn in astrocytes would logically lead to the assumption that a-Syn may be transported out of brain by the BBB.
The importance of CP transport to brain parenchyma has long been debated.
