Because Gd-EOB-DTPA uptake is mediated by the same transporter that is responsible for bilirubin transport, biliary obstruction or diminished hepatobiliary function can be suspected in patients with reduced or no visualisation of the biliary tree 20 30 min after Gd-EOB-DTPA administration [ 21, 26, 27].
In addition, the ability to discover pathological conditions such as focal lesions or blunt trauma in parenchymatous organs, perfusion disorders in vascular problems such as arterial or venous occlusion, aneurysm, etc., outflow obstacles such as in acute biliary or urinary obstruction, or transport problems in intestinal obstruction (ileus, subileus).
The underlying toxicity of the aggregates themselves is likely to go beyond these effects on protein homeostasis and will furthermore directly impair other functions, such as axonal transport, organelle dynamics (physical obstruction or cytoskeletal collapse) and membrane integrity.
Winds at the surface are slow, moving at a few kilometres per hour, but because of the high density of the atmosphere at the Venusian surface, they exert a significant amount of force against obstructions, and transport dust and small stones across the surface.
The neurotrophin (NT) hypothesis proposes that the obstruction of retrograde transport at the optic nerve head results in the deprivation of neurotrophic support to retinal ganglion cells (RGC) leading to apoptotic cell death in glaucoma.
The hypothetical underlying mechanisms for infertility due to IUAs are obstruction of sperm transport into the cervix, impaired embryo migration within the uterine cavity, or failure of embryo implantation due to endometrial insufficiency [1].
These studies highlight the types of attacks and interferences with healthcare including damage or destruction of health facilities, occupation and armed entry of premises, arrests, kidnappings and intimidation of health providers and patients, and attacks on and obstruction of health transports [ 9].
This plateau level of translocation is most likely caused by an obstruction of the transporter channel by newly transported NBD-labelled Lipid II that is bound by vancomycin-TMR.
These numerous fluorescent vessels were observed due to obstruction of normal lymph transport and thus rerouting of lymphatic drainage via multiple vessels into the ILN.
Using live imaging, we show that the vesicles located within axonal swellings display Brownian motion that is reminiscent of that described for microtubule-uncharged cargoes, and that the local accumulation of organelles at the swelling proximal region results from delayed and impaired transport rather than from a complete obstruction of retrograde axonal transport.
