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Furthermore, increased ROS generation in the diabetic kidney enhances Na-K-2Cl cotransport activity, as shown in isolated mTALs [ 29], while impeding electrolyte transport efficacy (i.e., more oxygen demand per transport load) [ 22, 24].
OATP1B1 is polymorphically expressed, leading to significant variability in its transport efficacy for drugs as demonstrated for different statins in vitro and in vivo (Mwinyi et al. 2004; Niemi et al. 2004; Chung et al. 2005; Pasanen et al. 2007; Mwinyi et al. 2008).
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This cell model is widely used to investigate the transport, metabolism, and efficacy of dietary compounds in foods and metabolites generated during digestion [ 29].
Furthermore, we found that the efficacy of transport was dependent on the format.
The efficacy of transport depends on the electrical parameters and the physicochemical properties of drugs.
Kumar showed me a map of over 5,000 airports in the U.S. that are currently operating far under capacity, and explained that Zunum's goal is to change the face of air transport by maximizing the efficacy of this existing infrastructure.
A mathematical model of molecular transport predicted that SAH efficacy is primarily dependent on colony size and the rate of protein production.
Further, analysis of crystallization data using the Lauritzen Hoffman regime theory of crystal growth shows the PEO chains stiffen in presence of LDS with an increased energy barrier associated with the nucleation and crystal growth, and the nanotubes further act as a barrier to chain transport or enhance the efficacy of the LDS action.
The drug response was controlled by the combined effects of drug efficacy, drug transport limitations, cell growth, and angiogenesis.
In previous work we built upon these models to show how multiple nutrients interact to control cell growth and death (Venkatasubramanian et al, 2006) and how transport properties dictate the efficacy of cancer therapeutics (Venkatasubramanian et al, 2008).
Although many neural tracers are not transported in a purely anterograde or retrograde manner, most tracers have a greater efficacy in one transport direction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com