Here, it is shown that methods that strive to optimize velocity of transport may compromise efficiency.
In long-term patients, UFF is more severe and often associated with free water transport (FWT) compromise [ 4– 6].
Both MT overstabilization [ 7] and NF hyperphosphorylation could contribute to the destabilization of the cytoskeleton, affect axonal transport and compromise the overall integrity of the axon.
The oxygen transport is compromised as a result of abnormal levels of oxidized haemoglobin, and this leads to skin discolouration and a variety of symptoms.
Whereas, tau is an intracellular microtubule binding protein which, when hyper-phosphorylated, results in the disassembly of microtubules and thus leads to the impediment axonal transport and compromises neuronal and synaptic functions (Iqbal et al., 2005).
One interpretation of the persistence of ectopic proIAA2∶GUS activity in the vicinity of discontinuities in the vascular xylem is that auxin transport is compromised by a lack of coherence between vessel elements, allowing a local and ectopic accumulation of auxin.
The ability for auscultation during air medical transport is compromised by high ambient noise levels.
Previous work has established that microvascular oxygen transport is compromised in sepsis due to a loss of perfused capillaries.
Nevertheless, hyperphosphorylation of tau negatively regulates the binding of tau to microtubules, as a result of which microtubule stabilization and axonal transport are compromised.
Still, one is wondering whether you could provide raw data of the phosphoproteomic analysis (i.e. what peptides where found, how many, etc).? 3) There is one genetic experiment that the reviewers had a hard time interpreting: the PIN1S4A variant can rescue a pin1 null mutant, yet basipetal transport is compromised.
