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Despite some tumorigenic characteristics of our hMSC cell transplants (high degree of Ki67-positivity, multiple mitoses, central necrosis, neovascularisation,... (data not shown)), total regression was seen over a 2-week period after cessation of systemic immune suppression.
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A degree of caution should thus be applied to interpreting data from mammary cell transplantation experiments that incorporate Matrigel, particularly when transplanting high cell numbers.
Due to the lengthy list of patients requiring transplant, high mortality rates are observed during the endless waiting period.
This caveat should be considered when interpreting mammary reconstitution assays that incorporate Matrigel, particularly when transplanting high cell numbers.
In the polymer-coated urea treatment (PCU180) during the period 20 to 40 days after transplanting, higher denitrification rates and N2O fluxes occurred.
Older age, bone marrow transplant, higher SOFA score and mechanical ventilation or RRT were independently associated with poor outcome.
Older age, bone marrow transplant, higher SOFA score and/or need for mechanical ventilation or RRT predicted poor outcome in IA.
Age, baseline left ventricular ejection fraction (LVEF), radiation therapy on cardiac area, exposure to anthracycline, single or multiple transplant, high-dose agents, trastuzumab treatment duration were recorded as potential risk factors.
Among patients with proven or putative IA, independent risk factors for mortality were older age, bone marrow transplant, higher SOFA score and need for mechanical ventilation or RRT on the day of positive Aspergillus culture (Table 5).
But transplants carry high morbidity and mortality and it had become apparent with time that this patient's trajectory would not be altered by a transplant.
Even after she received corneal transplants during high school, her corrected vision never improved beyond the range of 20/200 to 20/400 for her overall vision.
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