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This large cohort of US solid organ transplant recipients, for whom cancer ascertainment was conducted uniformly via linkage with population-based cancer registries, enabled us to quantify the risks of specific subtypes overall and according to recipient age at transplantation, type of transplanted organ, and time since transplant.
They were also evaluated for current age, age at time of transplantation, type of organ transplant, gender, tacrolimus use, history of transplant rejection, Epstein-Barr virus (EBV) serology, and cytomegalovirus (CMV) serology.
Antibodies to the tumour-specific transplantation type antigen (TSTA) of a transplanted methylcholanthrene-induced sarcoma (MC-1) in syngeneic rats were studied using the techniques of indirect membrane immunofluorescence and mixed haemadsorption with a Cr-labelled indicator cell.
We aimed to analyze the characteristics and outcomes of transplantation type in these children, adolescents, and young adults.
Transplantation type, SLT versus DLT, did not affect survival outcome.
The following information was collected for all patients: basic data, comorbidities, primary diagnosis before HSCT, transplantation type (e.g., allogeneic HSCT (allo-HSCT) or autologous HSCT (auto-HSCT)), TBI, use of immunosuppressive agents, and cGVHD status.
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However, when BLT vs. SLT survival was assessed using IPF patients matched on potential risk factors, there was no significant difference between transplantation types (P = 0.3).
The heterogeneity of the populations (transplantation types and preemptive KT vs. dialysis before KT) can be the other limitation of this study although we verified such clinical findings were not different between the MIA score groups.
Serological experiments support the conclusion that the antigen involved-referred to as "Ho-SAL -has tHo-SAL -hases of a tumour specific transplantation-type antigen for SAL cells but is a widely expressed alloantigen found in botHo-SAL -hasd malignantheells derived from Hooded rats.
In confirmation of other studies it has been shown that antibody directed against the tumour specific transplantation-type antigens (TSTAs) cannot be detected in rats with a tumour growing intramuscularly but appears within a few days after excision of the tumour.
Two of these were antigenic in the syngeneic host, one was unique to the MC1 tumour and could not be detected in embryo tissue and has the properties to be expected from the well established tumour-specific transplantation-type antigen while the other, referred to as OEA I, was present in all rat sarcomata tested as well as in early embryos.
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