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This makes it very difficult, if not impossible, to remove PERV sequences from transplantation source pigs [8], [11], [12], [13], [14], [15], [16].
These characteristics are clear advantage of hAMCs, making them potentially superior to bone marrow-derived cells as a cell transplantation source.
Therefore, development of transplantation source animals with reduced PERV activity, development and refinement of clinical tests for PERV transmission, and accurate preclinical risk assessment, are much needed.
The harvesting of bone marrow derived MSCs in patients is a common procedure and has low morbidity, thus making these cells attractive as potential cell transplantation source.
In summary, our study demonstrates that individual perception of quality of life benefits of kidney transplantation; willingness to attend class on kidney transplantation; source of information about kidney transplantation; and perceptions on whether a living person can donate a kidney, are significant factors affecting willingness to undergo a kidney transplant particularly among AAs.
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We also obtained the information related to transplantation: donor source, type of immunosuppression, initial graft function, acute rejection episodes, and time after transplantation.
All aspects of organ transplantation are a source of uncertainty.
Donor factors such as age at transplantation, sex, donor source, and CMV IgG status were evaluated.
One accepted treatment for variant ATTR amyloidosis is liver transplantation where the source organ of variant TTR production is exchanged by another producing wild type only.
To our knowledge, this study is the first to report willingness to attend a class on kidney transplantation and the source of patient information for kidney transplantation as being associated with willingness to undergo a kidney transplant in pre-dialysis CKD population.
Finally, among participants who had heard about kidney transplant, the source of information (other sources vs. physician) was significantly associated with participant's willingness to undergo kidney transplantation.
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