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Therefore, little is known about the risk factors and disease behavior in the transplant setting.
The use of prophylactic ECP may provide an alternative and safe method for immunosuppression in the bone marrow transplant setting.
Malnutrition is known to increase morbidity and mortality in renal transplant recipients whereas little is known about genetic predisposition to low BMI in transplant setting.
However, the release of platelet derived CD154 and its consequences have not been investigated in a clinical transplant setting.
The potential transfer of mismatched Class I HLA antigens between cells as identified in this study has implications for graft acceptance in the bone marrow transplant setting.
T cell depleting strategies are an integral part of immunosuppressive regimens widely used in the hematological and solid organ transplant setting.
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Indeed, following the results of several studies, the standard of care has become administration of LAM in the pre-transplant setting (ideally, at least four weeks prior to transplantation) followed by the combination of LAM and HBIG in the post-transplant setting.
Also, these drugs are being increasingly used in the peri-transplant setting for transplant-eligible patients, and as part of consolidation and/or maintenance after front-line treatment, including in transplant-ineligible patients.
Bortezomib is currently undergoing investigation in frontline treatment in both the transplant and non-transplant setting.
It is expected that the development of ADV mutations will similarly become a problem in the post-transplant setting.
In contrast to monotherapy, LAM in combination with HBIG has been potent in preventing the recurrence of HBV in the post-transplant setting.
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