Research in transplantation tolerance relies on application of successful strategies in a nonhuman-primate organ transplant model for preclinical testing.
Stepwise progression of CRC disease in the orthotopic transplant model.
Riella, L. V. et al. Deleterious effect of CTLA4-Ig on a treg-dependent transplant model.
Comparison of APC silenced and APC-restored tumors in the shAPC.8745e transplant model.
Inoue, S. et al. Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model.
Martin, E.S. et al. Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
Selenbp1 inhibits clonal growth and migration and suppresses growth of metastases in an in vivo transplant model.
Recapitulating our findings in the simultaneous transplant model, BALF of animals from the infected + PiMT group showed reduced erythrocyte levels compared to infected, non-transplanted controls (Fig. 5h).
Pre-clinical studies showed that col(V -induced immune tolerance abrogated acute rejection in a rat lung transplant model.
The bone marrow transplant model of MPLW515L-mediated myeloproliferative disorders (MPD) exhibits certain features of human MF, including extramedullary hematopoiesis, splenomegaly, and megakaryocytic proliferation.
Distinct from the JAK2V617F retroviral transplant model, the MPLW515L model recapitulates many features of ET and MF, including severe fibrosis and thrombocytosis.
