Sentence examples for transmitter uptake from inspiring English sources
Thereby, transmitter uptake by GAT-1 and EAAC1 provides a direct coupling between actual network activity and inhibitory synaptic strength.
This delayed block of transmitter uptake should de-potentiate mIPSCs if enhanced activity of the transporters was required throughout the maintenance of the effect.
This shows that the terminals of inhibitory neurons are highly sensitive and rapidly acting detectors for extracellular transmitters [38], [39], making presynaptic transmitter uptake a crucial element in homeostatic plasticity of hippocampal networks.
METH is a substrate for the dopamine transporter and profoundly increases the concentration of extracellular monoamines dopamine (DA), serotonin (5-HT), and norepinephrine (NE) by redistributing these neurotransmitters from synaptic vesicles to the cytosol, in addition to inducing reverse transport and competing for transmitter uptake at their cognate transporters [8].
The fine perisynaptic astrocyte processes, on the other hand, were shown to harbor a distinct molecular profile mirroring their specific roles in transmitter uptake (Chaudhry et al. 1995).
They have high-affinity transmitter uptake systems and voltage-dependent and transmitter-gated ion channels and can release transmitter, but their role in signalling is not well understood.
A possible mechanism for such activity-dependent, rapid adaptation is uptake of transmitters from the extracellular space.
Thus, uptake of transmitters from the extracellular space is crucial for the maintenance of inhibitory efficacy even under conditions of low synaptic activity in the hippocampal network.
Finally, we reversed our experimental approach, trying to reduce vesicular GABA filling by blocking uptake of both transmitters.
They are rather consistent with uptake of the transmitters immediately after the stimulus which increases extracellular concentrations of GABA and glutamate.
These autoreceptors actually trigger a strong inhibition of 5-HT neuron firing rate, counteracting almost totally the passive elevation of 5-HT extracellular levels that the above cited molecules induce by blocking the inactivation (catabolism or re-uptake) of the transmitter [9] [10].
