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A systematic transmission study of 10B enriched steel plates by means of neutron time-of-flight and neutron radiography experiments was performed.
In a transmission study of the virus with all four mutations, six out of six ferrets became infected when housed in a cage close to an animal that already carried the virus, allowing the virus to transmit through sneezing and coughing.
A transmission study of lymphoid tissues to mice is in progress.
A transmission study of atypical scrapie to transgenic mice expressing ovine PrP confirmed the infectious nature of the disease and also suggested that the atypical cases were caused by a unique strain [ 15].
To grasp the whole picture of the phenotypic variability and PrPSc strain diversity in the MV2 subgroups, a transmission study of MV2C is in progress using the PrP-humanized mice.
We previously reported a transmission study of atypical BSE in cattle to generate tissue for reference and European quality assurance, which produced pathological and molecular phenotypes consistent with the original source (H-type and L-type BSE) but it produced two clinical phenotypes: a nervous form, and a dull form only seen in cattle with the longest survival time [ 4].
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"As the risks of such research and its publication are debated by the community, I argue that we should pursue transmission studies of highly pathogenic avian influenza viruses with urgency," he writes in Nature.
Regarding the TgOvPrP4 mouse line, the presence of [TgOvPrP4 (x0.25)] animals which express low levels of PrPc clearly represents a drawback for transmission studies of TSEs.
We previously reported that, during transmission studies of classical scrapie and BSE, some inoculated TgOvPrP4 mice failed to accumulate detectable levels of PrPres in their brains [20].
To confirm and develop these ideas, future research should focus on large-scale genomics and transmission studies of TBEV isolates recovered from patients and ticks.
All these parameters were similar in the transmission studies of primary and secondary vCJD in transgenic mice, indicating that the strain properties of the vCJD agent have not changed significantly following secondary passage in humans.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com