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The heretical idea that prions--naked protein particles without a stitch of genetic material--can cause transmissible disorders such as mad cow disease and Creutzfeldt-Jakob disease (CJD) in people has just received a big boost.
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Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans.
Prion diseases are transmissible neurodegenerative disorders characterized by neuronal loss, astrocytosis and deposition of the pathogenic isoform (PrPSc) of the cellular prion protein (PrPC).
Clinical issue Prion diseases are aggressive, transmissible neurodegenerative disorders that often have long incubation periods.
The transmission of prion protein (PrP) shows the role EVs play in the mechanism of transmissible neurodegenerative disorders [ 37].
Prion diseases such as Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy (BSE) are transmissible neurodegenerative disorders.
Prion diseases, such as bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep, and Creutzfeldt-Jakob disease (CJD) in humans, are fatal, transmissible, neurodegenerative disorders associated with the aggregation of an infectivity-associated isoform (PrPSc) of the cellular prion protein (PrP) (1 ).
Sporadic CJD (sCJD) is a transmissible neurodegenerative disorder with a fatal outcome.
Both sporadic and genetic prion disorders are transmissible to a wide range of laboratory animals (rodents, felines, and non-human primates) by the injection of crude brain homogenates.
Prion diseases are transmissible fatal neurodegenerative disorders affecting humans and animals.
Prion diseases are a group of transmissible neurodegenerative lethal disorders in humans, cattle, sheep, elk, mink and experimental animals.
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