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Statins thus inhibit interactions between leukocytes and endothelial cells, preventing leukocyte transmigration from the vasculature, across the blood-retinal barrier [29, 32 34].
However, relatively little is known about the molecular cues that regulate the entry of immune cells from peripheral, nonlymphoid tissues into afferent lymph vessels and, in particular, their subsequent transmigration from afferent lymphatics into the parenchyma of draining lymph nodes (LNs).
Other theories about the origin of the bacteria, such as through the portal vein or transmigration from the colon, are considered less likely.
Previous studies demonstrated a key role for cell-surface heparan sulfate (HS) proteoglycans (HSPGs) in regulating leukocyte transmigration from blood to sites of inflammation [ 27, 33, 60].
The Gas6-AXL pathway is involved in tumor stimulating actions such as stimulating growth and invasion as well as in anti tumor actions, increasing leukocyte transmigration from vessels important in tumor targeting [ 47- 51].
We have detected leukocyte infiltration in decidua from Stx2-treated rats, which could be the result of transmigration from the blood microvasculature to decidua tissues due to endothelial damages caused by Stx2 [ 29].
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However, Hck / Fgr /– mice were also protected from LPS-induced early acute lung injury, in particular from transmigration of neutrophils from the blood to the bronchoalveolar lavage fluid (G. Berton, personal communication).
In Madhva's time, most Hindus believed in heaven and hell as well as in a process of transmigration (samsara) from which it was possible to attain release (moksha).
We have developed a porcine and human "inverted" culture insert system that enables leukocyte transmigration specifically from the physiologically relevant basolateral side.
Many schools teach that it is through divine grace that the votary is lifted from transmigration to release.
For Ramanuja, release (moksha) is not a negative separation from transmigration, or a series of rebirths, but rather the joy of the contemplation of God.
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