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Cloned type III secretion systems have much potential to be used for bacterial engineering purposes involving protein secretion and substrate translocation directly into eukaryotic cells.
On chromosome 1, the t(1 11) translocation directly disrupts DISC1 and its non-coding antisense partner DISC2 (2).
HIV-1 infection is indeed associated with a significant increase of plasma lipopolysaccharide levels that is an indicator of microbial translocation, directly correlated with measures of immune activation.
GRIA3 was first identified as a candidate gene for X-linked ID in 1999, in a female with a balanced translocation directly involving this gene.
Future studies, monitoring BoNT translocation directly at the terminals of different classes of neurons, especially at the neuromuscular junction, will shed light on this issue.
Seminal work by Brenchley et al. suggested that microbial translocation directly contributes to systemic innate and adaptive immune activation during chronic HIV infection and may affect the progression rate of AIDS [ 208].
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The recessive beneficial advantage would then be one of maintaining optimised fertility, but the process would certainly be much more direct, and thus favoured if the chromosomal translocation was directly associated to a mutated gene leading to an advantageous phenotype.
The magnitude of βγ translocation is directly correlated with increasing agonist concentration.
Furthermore, overexpression of ERG (as a result of fusion between the TMPRESS2 and ERG from chromosome 21 translocation) can directly activate EZH2.
Increased levels of GLUT4 in the plasma membrane due to an increase in gene expression and/or translocation are directly correlated with improved insulin sensitivity [ 6].
DNA translocation was directly observed in real-time by single-molecule imaging microscopy to detect fluorescence images revealing the displacement of the bead [ 49, 51].
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