Sentence examples for translational targets from inspiring English sources

Furthermore, we found that mRNAs that display alternative splicing changes upon SRSF1 overexpression are also its translational targets, strongly suggesting that SRSF1 couples pre-mRNA splicing and translation.

Changes in telomere length associated with type 2 diabetes (T2DM) and interactions between mitochondrial function and telomeres represent possible translational targets to treat T2DM by restoring telomere length [13 16].

Arguably, nowhere has there been a greater advance in our understanding of biological mechanisms and potential translational targets during the next-generation sequencing era than in paediatric brain tumours.

70% of the money will go towards funding dream teams, across institutions and across disciplines, focused on specific translational targets designed to get new therapies to patients as quickly as possible.

Identification of SRSF1 mRNA translational targets.

10.7554/eLife.02028.009 Figure 3. Validation of SRSF1 translational targets.

(A ) Experimental approach to identify SRSF1 mRNA translational targets.

Supplementary file 1. List of SRSF1 translational targets.

Only mTOR translational targets are plotted (colored light green).

(B ) Box plot showing the density of consensus motif (translational targets CLIP+ > translational targets CLIP− > null CLIP+ > null CLIP+).

Importantly, ISRIB abolished the induction of the known phospho-eIF2α-dependent translational targets and the seven ISR-translational targets with previously identified uORFs.