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Good candidates contained long tracts in the appropriate position to mediate translational switching.
A translational switching mechanism is proposed.
In a carefully designed shuttle reported by Stoddart et al., translational switching was obtained by one-electron reduction of a viologen station by a ruthenium trisbipyridine stopper.
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Since we show that SIRT1 mediated deacetylation of Foxp3 results in impaired protein stability, we propose a model in which Foxp3 acetylation may provide a post-translational "switch" allowing the development of iTreg.
Open image in new window Fig. 5 Monorail translational switch.
Moreover, RNA motifs recognized by RNA-binding proteins can be applied to make protein-responsive translational "switches" that can turn gene expression "on" or "off" depending on the intracellular environment.
Although there is no proof so far that such a translational switch of the start codon occurs in vivo for Mca1 or any other prion-like protein, we consider such a hypothesis as very attractive.
Upon dietary restriction, a translational switch to nuclear-encoded mitochondrial genes occurs in a 4E-BP-dependent manner (Ref. 106).
Recent work has highlighted the importance of protein translational switches during times of cellular and environmental stress, and the role of 4E-BP in this process.
One interpretation of our results is that daf-2 e1370) daf-2 e1370rgo adultslar translational switch to repress YP synthesis in early adundergo.
Here we use an RNA/protein interaction-based synthetic translational switch to create a feedback system that tightly controls the expression of proteins of interest in mammalian cells.
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