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It has been suggested that the differences in translational speed and the occurrence of pauses in translation is tightly linked to the folding mechanisms of the respective protein [ 9, 10], with clustered rare codons having a greater effect on translational speed than separated rare codons [ 11].
The selection-related model postulates coadaptation between synonymous codon usage and the translation machinery (e.g., differential transfer RNA [tRNA] abundance) to optimize translational speed and enhance translational accuracy (Sharp et al. 1995; Duret 2000; Rocha 2004).
The synonymous codon usage and translational speed of gene play important roles in many biological functions, like translation efficiency, genetic diversity, amino acid conservation, transfer RNA abundance, coevolution of the virus and its hosts, and context-dependent codon bias (CDCB), and so forth [ 18– 22].
This suggests that selection is occurring during the process of translation, likely mediated by the thus far unrecognized effects of G+C contents on translational speed or accuracy, or on mRNA secondary structure and stability.
Yang, J.R., Chen, X. & Zhang, J. Codon-by-codon modulation of translational speed and accuracy via mRNA folding.
Upon looming onset, flies first sharply decreased their translational speed after which they showed a rapid burst of locomotion (Fig. 3f, marker #2 and 3).
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The two faster translational speeds showed transformation rates > 45 vol%/s and a partially martensitic microstructure.
The effects of the rotational and translational speeds and carrier eccentricity are discussed.
Indeed, direct relationships between particular amino-acid compositions and translational speeds were found [ 22, 35].
Needle rotation and axial translational speeds were 6 revolutions/sec and 10 mm/s respectively.
A technique called "ribosomal profiling" allows inferring relative translational speeds at the nucleotide resolution, indirectly as the inverse of the ribosomal occupancy [ 19].
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