Sentence examples for translational route from inspiring English sources

Furthermore, because of the possibility of overlap among existing patent claims surrounding cffDNA testing, the enforcement of patents through infringement suits may have a drastic effect on the translational route of this testing.

This indicates that AQP2-R254W may follow a different post-translational route than AQP2-WT and that the majority of AQP2-R254W does not reach sub-apical vesicles and the plasma membrane.

We synthesized the corresponding l- and d-pipecolyl-CoAs (in this case the 2 S and 2 R isomers, respectively; the 3 S and 3 R numbering in piperazate starts from the first hydrazo N) and used the Sfp-mediated post-translational route to yield the corresponding pipecolyl-S-KtzC protein thioesters as potential substrates.

M.D.-Ph.D. programs are well established in the United States and have offered a route for translational research training for decades.

Based on our experience, we propose that the translational medicine platform (TMP) is an effective route to facilitate the progress of biomedical materials from bench to bedside.

Combination of this approach with intein-catalyzed protein splicing furnished an efficient route to achieve the spontaneous, post-translational formation of structurally diverse macrocyclic peptides in bacterial cells.

Apart from the obvious benefits of animal wellbeing, the delivery of investigational drugs with food pellets can increase the validity of translational models as it simulates a human equivalent therapeutic dosing route.

Although specific neuronal types can be isolated from rodent embryos or engineered from stem cells for translational studies, transcription factor-mediated reprogramming might provide a more direct route to their generation.

Overall, a clearance route has been revealed in the early post-translational processing of proinsulin that is characterized by marked ATP/redox sensitivity (yin) counterbalanced by a maturation route that is partially dependent upon ATP (yang).

Together, these results suggest that IRES elements provide an alternative route by which specific mRNAs continue to be translated when the proper functioning of the cap-dependent translational machinery becomes compromised.

Since large animal models enable clinical treatment regimens, delivery route, and identical function-related measurements, they are considered to withhold greater translational value than small animal models and are therefore superior for efficacy testing [ 6– 10].