However, obstacles for using LCLs to identify clinically relevant loci include elucidation of the translational relevance between donor and LCL, and the development of methods that are powerful for using DR data in gene mapping.
Critically, to achieve maximum translational relevance, we paid special attention to candidate targets for which there were clinically relevant pharmacological inhibitors.
Furthermore, we detail the translational relevance of these mechanisms to clinical readouts in human LN.
The data so far emphasise the relatively high translational relevance of animal models in this area of behavioural neuroscience.
In addition, recording technique, clinical context and adjustment for incident heart rate are key factors to consider when interpreting the translational relevance of HRV in critically ill patients.
In this review, we discuss the translational relevance of EMT mechanisms in HNC and integrate these findings with the novel molecular picture emerging for this heterogeneous disease.
It promotes a dedicated discussion on the topic of the translational relevance of biomarkers and enables efficient identification of translational gaps and opportunities.
This study investigated PTEN phosphatase-dependent and phosphatase-independent morphogenic functions in 3D models and assessed translational relevance in human studies.
Furthermore, these CRMs resulted in robust and sustained liver-specific expression of coagulation factor IX (FIX), validating their immediate therapeutic and translational relevance.
TRANSLATIONAL RELEVANCE: The combination of radiotherapy and androgen deprivation therapy is a standard treatment option for men with high-risk prostate cancer.
In this review, we discuss the significant advancements in our understanding of its genetics and molecular biology and their translational relevance.
