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The translational prospect of this trial turned out to be low because of the chosen comparator.
In contrast, the translational prospect of a clinical trial does change between phase I, II and III.
Here, for early human trials, the validity, translational prospect, and the anticipated social value are all weighed against the risks the research participant would take.
To clarify the distinctions, I will give an example of a clinical trial with limited translational prospect of an intervention with high anticipated social value.
The validity of a trial needs to be judged by an expert methodologist, and is more straightforward than both the anticipated social value and the translational prospect.
This we will call the translational prospect of a clinical trial because it specifically addresses the likelihood a clinical trial will assist in the translation of the intervention (and thus not its value).
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Moreover, defining pathways that regulate chronic stage of disease might have better translational prospects considering that all interventions in MS occur long after the onset of disease.
From a clinical perspective, there is growing interest in the prospects of translating the results of airway microbiome analyses into practical patient-management tools for lung diseases; but in order to accelerate translational prospects of airway microbiome research, several challenges will need to be addressed.
If further work elaborating our novel pyrimidinone scaffold succeeds and the role of plant-type chitinases in A. fumigatus biofilm maturation is conclusive, this would open up translational prospects perhaps one day leading to the clinical use of chitinase-inhibitors as anti-biofilm agents.
Only by giving the same attention to bridging science policy's valley of death as we do to biomedical research translational process, prospects can be favorable for the effective translation of science into collective benefit.
The availability of ASL on dedicated preclinical imaging systems makes translational research an enticing prospect.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com