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However, miRNA-29a-c and HIV-1 DNA integrated levels were quantified only in total PBMCs, and may have missed differences in various cell types, such as resting central memory T cells and translational memory T cells, which serve as major sites for HIV-1 latency [ 28].
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For the present study, 74 subjects with MCI were selected from a prospective study on the natural history of cognitive impairment (the translational outpatient memory clinic TOMC study) carried out in the outpatient facility of the National Institute for the Research and Care of Alzheimer's Disease IRCCS Istituto Centro San Giovannii di Dio Fatebenefratelli, Brescia, Italy).
Together, these findings reveal the multifaceted role of LoNA in modulating ribosome biogenesis to meet the translational demands of long-term memory.
Activation of this pathway is necessary for both the transcriptional and translational events underlying long-term memory formation in the hippocampus.
Richter, J. D. & Klann, E. Making synaptic plasticity and memory last: mechanisms of translational regulation.
The mouse cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is a translational regulator implicated in long-term memory maintenance.
It is therefore conceivable that altered local translational regulation may compromise learning and memory in dementia and other neurodegenerative disorders.
These results reveal a novel translational underpinning for protein synthesis pertinent to memory consolidation in the mammalian brain.
In this report, we provide compelling evidence at the molecular, pharmacological, genetic, and behavioral levels that post-training dephosphorylation of eEF-2 is a key translational mechanism for protein synthesis pertinent to memory consolidation in the brain.
This suggests that the induction of the long-lasting effect of SKF-38393 on memory formation requires mTOR-dependent translational changes in the cortex.
Together, these data support the role of REM-sleep neurobiology in the consolidation of emotional human memories, findings that have direct translational implications for affective psychiatric and mood disorders.
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