The current investigation makes this translational link, where loss of the lamin A/C protein accounts for the deformed nuclear morphology in a significant percentage of breast cancer (38% of the 56 invasive ductal carcinomas examined are lamin A/C negative).
Loss of translational regulators increases Myc mRNA, and conversely loss of Myc or Max strongly down-regulates genes involved in ribosome biogenesis.
Loss of translational activity leads to arrest at G1, whereas loss of the proteasome arrests cells at G2. dsRNAs targeting one gene that has previously not been linked to translation in Drosophila, Tango7, also resulted in expression profile that was very similar to that induced by loss of the translational initiation factors eIF-4a, eIF3-S10, and CG8636/eIF3-S4.
It will be important to determine whether the sustained repression in presynaptic mRNA translation, as opposed to global translational, contributes to neuronal loss in neurodegenerative diseases.
These studies suggest that excessive translation due to the loss of a translational brake (FMRP) results in the development of aberrant neuronal connections and the behavioral manifestations of fragile X syndrome in adulthood.
The importance of the association free energy, arising from one molecule's loss of translational and rotational freedom from the standard state concentration, is addressed.
Formation of a stereospecific protein complex is favored by specific interactions between two proteins but disfavored by the loss of translational and rotational freedom.
Due to the short half-life of IκB, translational attenuation results in loss of NF-κB binding and subsequent expression of pro-inflammatory cytokines, as demonstrated during L. pneumophila infection [1, 19].
Thus, the short alkanes can be treated as rigid rods, and the loss in translational and rotational entropy upon adsorption leads to a preexponential factor that increases with increasing chain length.
