Sentence examples for translational failure from inspiring English sources

In contrast, transcription and translation are uncoupled in eukaryotic cells, and translational failure rates are therefore significantly lower.

A stability analysis of reinforced jointed rock slope based on the kinematic approach of the yield design theory using two translational failure mechanisms is performed for evaluating passive fully grouted rock bolts.

A displacement method using the FLAC3D program is used to evaluate the response of piles caused by an embankment slope in a translational failure mode, induced by a weak soil layer or a liquefied layer beneath the embankment.

In prion-diseased mice, accumulation of misfolded prion protein (PrP) causes persistently high levels of PERK-P and eIF2α-P, and hence sustained translational failure.

The data support UPR-mediated translational failure as a generic pathogenic mechanism in protein-misfolding disorders, including tauopathies, that can be successfully targeted for prevention of neurodegeneration.

Here we show that PERK-eIF2α-mediated translational failure is a key process leading to neuronal loss in a mouse model of frontotemporal dementia, where the misfolded protein is a form of mutant tau.

Deficiencies in the design of human clinical trials is likely to explain many translational failures, at least in part.

This review article discusses the biology of the inflammatory response after myocardial infarction, attempts to identify the causes for the translational failures of the past, and proposes promising new therapeutic directions.

Comparisons demonstrate the reliability of the proposed rotational-translational failure mechanism for slopes with the weak interlayer, which can be used as a simple method for preliminary evaluation of slope stability in practical application.

Later, Soubra (2000) improved the solution of Chen and Rosenfarb (1973) by adopting the kinematical analysis of upper bound theorem with the translational multi-block failure wedge mechanism.

Intriguingly, in the ribosomopathy X-linked dyskeratosis congenita, ribosomes lacking pseudouridine are deficient in internal ribosomal entry site (IRES -dependent translatIRES -dependentn due translational the rinitiation bindueo toe IRES sequence [40], [41].