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It is tantalizing to imagine a world where that translational divide is bridged.
Second, it could preclude a promising drug from crossing the great translational divide, also known as the "Valley of Death" [ 79- 83], separating the pre-clinical and clinical studies.
I expanded this portion into suggesting that the systemic defect, such as glucocorticoid deficiency, can both make a seemingly promising drug to go further into clinical studies and subsequently rejected, as well as, more importantly, make an actually promising drug to fail in animal studies, and thus prevent it from crossing the translational divide.
Author's response : The anticipation of dramatic consequences, possibly associated with this problem, hinges on how much one believes in the existence of the great translational divide, also known as the Valley of Death", which separates pre-clinical studies from the clinical ones.
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As mentioned previously, the NIH divides translational research into five separate phases (i.e., stages T0 T4) (table 1 and figure 1), with T0 representing the basic research phase.
The exponential phase induction factors were calculated by dividing the translational repression factors in stationary phase with the translational repression factors in exponential phase.
Target motion may be divided into a translational component and a rotational component [13, 14].
Ejection process is mainly divided into the translational and coupling motion phases according to forces (including the hydrostatic and hydrodynamic) on the capsule and its corresponding motions.
The translational efficiencies were calculated by dividing the specific enzyme activities with the transcript levels.
Earth slides, the most common landslide movements in this area, are divided into rotational and translational slides.
In order to maintain the orthogonality of deformed grid, the displacement of grid points is divided into rotational and translational parts in this paper, and inverse distance weighted interpolation is used to transfer the changing location from boundary grid to the spatial grid.
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