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Medicine in general is particularly fascinated by the translational concept, probably for its peculiar applied scopes, and cardiology is not an exception.
Rolf Luft's clear-sightedness made it possible to fully establish the translational concept in medicine at the Karolinska Institutet/Karolinska University Hospital in Stockholm, and it was there that he went on to establish the Rolf Luft Research Center for Diabetes and Endocrinology, a state-of-the-art laboratory for cell biology and molecular biology.
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Clinical and translational medicine should be furthermore defined and differentiated from the understanding of other "translational" concepts, including translational science, translational research, translational medicine, or clinical and translational science.
This monograph is tenth in a series of articles focused on research design and analysis, and provides an overview of translational research concepts.
It is now clear that new translational science concepts will be adapted to make these advancements a reality.
Therefore, there is a need to set up an infrastructure with basic research and medical facilities with genetic testing and counseling for CAH patients so that better translational research concepts and intervention strategies are designed to help consanguineous couples for making informed and intelligent reproductive decisions.
Recommendation 3: Increase investments in health and biotechnology product development: Some of the recent increase in scientific funding could support and encourage proof of concept translational research.
Nevertheless, the integrative (pathway and gene expression) analysis strategy proposed here was indeed motivated to address this typical, and probably unavoidable, restriction in proof-of-concept translational research applications.
These individuals must be knowledgeable about the diverse aspects of clinical proteomics and able to integrate the translational and clinical concepts necessary for application to heart, lung, blood, and sleep diseases.
In conclusion, our data underline the role of translation factors for cell proliferation and support the concept of translational oncogenes.
However, the concept of translational research is not part of this progression, simply because the need for translational research – as part of therapy development – became evident long after the concepts of phase I to III trials were defined.
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