Sentence examples for translational capacities from inspiring English sources
Thus, unique biochemical properties could contribute to the distinct translational capacities of eIF4G variants and function in translational control.
Perhaps future studies could examine variables including the ERα ERβ ratio on the translational capacities of in vitro screening assays to effects in living organisms.
Because chloroplast primary transcripts are heavily processed – as just one example, the psbB cluster in maize accumulates as at least 15 distinct mRNA species with varying translational capacities [ 58] – direct analysis of the functional advantages of clustering in chloroplasts is challenging.
Given the apparent complex involvement of ERα and ERβ subtypes in generating the estrogenic response, the inclusion of multiple ER subtypes in screening batteries could provide insight into the mechanisms of estrogenic activity, as well as enhance the translational capacities of in vitro assays for risk assessment.
Recruitment to polysomes increases their rate of translation, thus increasing translational capacity.
We performed luciferase reporter translation assays to confirm that the translational capacity of the NF90 knockdown cells was not diminished.
These downstream effectors act to increase translation of select mRNAs that enhance overall translational capacity [6], [7], [8].
S6K1 activation up-regulates ribosome biosynthesis, and enhances cell translational capacity through phosphorylation of the 40S ribosomal protein S6 (rpS6) and upregulation of translation of mRNAs having 5'-terminal oligopyrimidine tracts (5'TOP), but in an mTOR-dependent, rapamycin sensitive manner [36], [37], [65].
This animal model was chosen for its translational capacity, i.e., developing adenocarcinomas with metastatic potential and its similarities to human luminal B breast tumors [21].
Very recently, it has been shown that the incorporation of N1-methylpseudouridine (m1Ψ) in mRNA resulted in innate immune evasion and increased translational capacity in vitro and in vivo [18].
The use of nucleoside-modified mRNA has previously been shown to improve the translational capacity and safety of mRNA-therapeutics, as it prevents the induction of type I interferons (IFNs).
