This collaborative presentation with painter & cellist Amy Kang and composer Ursula Kwong-Brown will explore color and vibration translational adaptations of Prelude of Bach's Cello suite #1.
Dictyostelium is a powerful model system for large-scale studies of the transcriptional and translational adaptations to a changing osmotic environment.
As these flies grew under normoxia through their entire life cycle, the stress-like behavior in metabolism may reflect the genetic differences rather than post-translational adaptation, although the gene(s)/mechanism(s) remain to be determined.
This manuscript by Preissler et al. furthers our understanding of post-translational adaptation to changes in ER homoestasis and focuses on the molecular basis of oligomerization of the molecular chaperone BiP.
Given the limitations and costs of transcriptional systems like the UPR to maintain homeostasis, a new focus has been placed on identification of more rapid post-translational adaptations that likely exist to adapt to changes in the ER protein load.
The inherent limitations and costs of the conventional transcriptional and translational UPR have generated interest in post-translational adaptations with shorter latency that rapidly match chaperone availability to client protein load.
Although this is deemed to be rate-limiting to translation [ 12, 32], more general translational efficiency can also be measured by the adaptation of all the uORF's codons to the organism's tRNA pool using the translation adaptation index (tAI) [ 33].
Thus, our data suggest that translational adjustment of C/EBPβ-isoform expression is one of the key processes that direct metabolic adaptation in response to changes in mTORC1 activity.
Speed of translation is an adaptation for translation rate whereas translational accuracy acts to minimize the incorporation of incorrect amino acids into proteins.
Several studies address the adaptation of translational efficiency to changes in environmental conditions like mild dehydration [ 8], hypoxia [ 9, 10], salt and high temperature [ 11, 12].
Major codon and amino acid preferences under high expression point toward adaptation for translational accuracy and/or efficiency (Akashi 2001; Akashi 2003).
