Sentence examples for translation to functional from inspiring English sources

MicroRNAs are small and non-coding RNA molecules that can regulate gene expression by interacting with multiple mRNAs and inducing either degradation of mRNA or inhibition of their translation to functional proteins [ 7, 14].

PTC124 is an orally bioavailable small molecule that is designed to induce ribosomes to selectively read through premature stop codons during mRNA translation, to produce functional CFTR.

Given that NF-κB is activated by inflammation, hypoxia, and ROS (Section  3.4.1), transcriptional upregulation of HIF1A by NF-κB and subsequent translation to a functional unit may be one of the most important regulatory mechanisms that influences HIF-1 signaling.

From these transformations, strains were isolated that contain retrotransposon insertions into pta and ack (Additional file 5) in the presence of the plasmid-encoded LtrA, which catalyzes mRNA splicing [ 19] and enables translation to produce functional Pta and Ack proteins.

All these findings suggest that MB exerts neuroprotection by regulation of the expression of soluble guanylate cyclase and diverse biological processes from inhibition of apoptosis and reversal of the shutdown of translation to restoration of functional cellular trafficking and activation of brain repair/regeneration genes as well as induction of critical neuroprotective proteins.

For a comprehensive view of A and B Edaradd isoforms history during mammal evolution, we obtained sequences for both isoforms in representative mammals and performed in vitro translations to support functional predictions.

Again, all the regions of high ribosome occupancy (i.e. slow translation) are associated to functional features.

Multiple sites are potential targets including the synthesis of LPL, the translation of mRNA to functional enzyme or the transfer of functional LPL from the cardiomyocyte to the endothelial surface of capillaries.

Protein folding is the subsequent critical process upon successful protein translation to ensure formation of functional proteins and this step usually requires the presence of chaperone proteins.

When (NLS) is periodic, we will use the invariance of the functional under translation to recover the compactness of the ( PS ) c sequence.

Analytical limitations remain to be overcome in the translation of functional microbiome surveys to human health, both in our understanding of basic biological mechanisms and in our ability to leverage these data for clinical use.