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They suggest that if transcription and translation were coupled, and because splicing is expected to have been slower than translation, the effect of insertion would have been ribosome readthrough into introns, resulting in production of aberrant proteins.
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Before clinical translation, the effects of SERCA2a were evaluated in a Yorkshire-Landrace swine model of volume-overload HF.
The modelers chose this mRNA length because it allows certain key properties of translation — the effects of the physical size of the ribosome on the accessibility of the start codon and the potential for "queuing effect" along the string — to be modeled.
Both of these indices allow easy translation to the effect size d equivalent (dhh for OR and dprobit for probit) and underestimate the true effect size much less and only at much more extreme test difficulties than dp or dphi [43].
The accuracy of the translation and the effect this had on the interaction with the parents is uncertain and could be viewed as a potential limitation.
The use of regional myocardial velocities is limited by the fact that the velocity of a certain myocardial segment is affected by global cardiac motion within the chest (cardiac translation) and the effect (pulling) of surrounding segments on the segment of interest (tethering).
We hypothesized that also in clinical translation, the therapeutic effect would be proportional to the number of engrafted cells that can be achieved with multiple injections.
Existing models of translation, already span a broad spectrum from the single ODE model to the detailed computational model of translation incorporating the effects of many factors [ 28].
Translation: The ill effects of bad debt are still working their way through the country's economic veins, and no easy remedies are available.
Translation of the effects of inhaled nicotine on the CNS into clinical settings could provide important health considerations.
Gladstone et al. report that Bouvardin, a compound previously identified in a Drosophila screen as an inhibitor of protein translation, enhances the effects of radiation and the anti-cancer agent taxol in several preclinical models.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com