This observation points to VLR affecting a combination of translation repression, post-translational modification regulation and nuclear protein stability.
Generally, miRNAs repress translation through deadenylation of mRNA leading to their subsequent degradation or translation repression.
RISC can promote target mRNA translation repression, degradation or both (Fabian et al., 2010).
In the present study, we confirmed that eIF4E2 is required for miRNA mediated translation repression.
MicroRNA (miRNA) and short interfering RNA (siRNA) are known to inhibit gene expression by mRNA degradation and/or translation repression.
We achieved this goal by transformation of a permanently active variant NAB1* of the LHC translation repressor NAB1 to reduce antenna size via translation repression.
AGO1 catalyzes broad miRNA- and siRNA-guided mRNA cleavage and translation repression [8], [9], [10], [11].
AGO10 appears to be limited to miRNA- and siRNA-guided translation repression [9].
Other genes are involved in transcription regulation including RGL1, and TBX3 or translation repression (SAMD4).).
A single vertebrate miRNA can target hundreds of mRNA transcripts for either translation repression or degradation [24], [25].
Therefore, the co-degradation mediated by mRNA-sRNA complex is more efficiently to induce bistability than the translation repression process.
