Accordingly, changed network topology suggests altered regulation or regulatory uncoupling of co-expression and co-translation relationships.
To investigate co-expression and co-translation relationships on a global scale, we computed the correlation of the adjacency matrices of both networks.
For each gene, the EC, i.e. the similarity of the gene's genome-wide co-expression and co-translation relationships, was calculated.
In addition, a high degree of uncoupling between transcription and translation was observed when investigating correlations in co-expression and co-translation relationships.
Specifically, both a co-expression and a co-translation network were constructed based on the common cell-type-specific transcriptome and translatome data to further identify the co-expression/co-translation relationships of genes which differ between the two networks.
Returning to a per-gene analysis, we investigated which genes either significantly deviated or correlated in co-expression and co-translation relationships (i.e. EC scores) by assessing statistical significance by Z-scores and bootstrapping.
Due to the high number of genes with uncoupled co-expression and co-translation relationships, i.e. low EC scores, we found numerous GO-BP term enrichments, including a wide range of metabolic and catabolic, as well as transport processes.
"The literal translation means relationships, but relationships can be defined in lots of different ways," said Eric Olander, a media specialist with more than 20 years' experience in China.
As a sort of antithesis to the usual curatorial process, rather than conceiving connections through a symbiosis between aesthetic and message, X + 1 is primarily highlighting the network activity and exchanges, and this translation of online relationships created are subsequently transcribed through a unique and immersive visual experience". .
