This article describes an "evidence integration triangle" (EIT) to guide translation, implementation, prevention efforts, comparative effectiveness research, funding, and policymaking.
However, with the current worldwide burden of new cases of diabetes and with the associated complications and comorbidities, the need for more rapid clinical translation of prevention strategies is not in question.
In this issue of Diabetes Care, two studies are reported on by the DPP Research Group in follow-up of the DPP and the DPP Outcomes Study DPPOSS) and address some of the relevant issues related to the translation of prevention strategies.
Both modifications, either to the tRNA or to the ribosomal S12, could lead to alteration of functions potentially important for carrying out efficient and accurate ribosomal translation, whereas prevention of such modifications in organisms such as bacteria could lead to antibiotic resistance.
The mechanisms underlying translational regulation of the p53 tumor suppressor and the role of p53 translation in the prevention of tumorigenesis are significantly understudied.
Colditz, G. A., Philpott, S. E. & Hankinson, S. E. The impact of the Nurses Health Studyy on population health: prevention, translation, and control.
Other reviews have assessed the translation of diabetes prevention studies into 'real-world' settings.
The translation of falls prevention interventions into clinical practice is difficult and requires further investigation.
Peer-led education is one recommended approach to facilitate translation of falls prevention messages to community-dwelling older adults [ 11, 12].
On all of these fronts, the individual patient receiving appropriate and targeted interventions that are meaningful, feasible and that they are motivated to implement, remains central to effective translation of falls prevention research evidence into practice.
