The overlap of both the in silico prediction analysis (resulting in sORFs with high coding potential) and the ribosome profiling data (suggesting translation) could potentially yield functional micropeptides.
In addition, ORF length appears as a strong determinant of ribosome occupancy in this class and thus of translation efficiency (potentially due to the lack of post-transcriptional regulation, see Additional file 1: Figure S11) [ 32].
This isoform contains exons 2, 4, 5, 6, 7 etc (accession number BG772375) and the ATG codon is found in exon 4 where it directs translation to potentially produce the original 54.1 kDa TR1 protein [ 8].
Thus, follow-up experiments in suitable preclinical MPN animal models [ 52- 54] would be important for proof of concept in vivo and to support the translation of potentially promising therapeutic modalities into the clinical setting.
Given that both foci formation and RAN translation are potentially pathogenic, we examined the relationship between foci and inclusions composed of poly(GP), which is RAN translated from both sense and antisense transcripts.
This process of translation will potentially encounter at least three roadblocks: between basic science and "first in man" studies; between efficacy and effectiveness trials; and between the formulation of clinical guidelines and the delivery in routine clinical practice.
tRNA halves, corresponding to the 5' or 3' sequences of the tRNAs, derived from mature tRNAs cleaved at their anticodon loops by an unidentified RNase, were able to inhibit translation and potentially transmit long-distance signals in plant phloem sap [ 27].
In addition, the ability of ERα to regulate gene expression at the transcriptional level, and to modulate the activity of signaling pathways that impinge on mRNA translation efficiency, potentially adds a layer of complexity to the gene expression program of ERα in cancer cells.
Further, there was no language restriction, and translations of potentially relevant titles and articles were obtained.
47 There was no language restriction used for inclusion of studies, and translations of potentially relevant titles and articles were conducted.
