Two more books are presently under translation: Possibility and Actuality and Aesthetics (both are scheduled to appear in 2013, see Hartmann 2013a,b).
Because of this back-translation possibility, we refer to the resulting two models as two degrees of zooming of the same model.
With the wide range of cellular activities attributed to INT6, the mechanistic detail of this control remains to be understood; our early investigations indicate reduction of MEK1 in INT6-siRNA treated mammalian cells is not dependent on the proteasome (M.G. & C.J.N., unpublished data), making direct MEK1 regulation by INT6-dependent translation a possibility.
-are active RecJ-like proteins involved in processes other than replication, such as DNA repair or even translation, a possibility that is suggested by their conserved genomic context?
However, predicted RBPs did not feature prominently on the list of regulated transcripts, which argues against a general model of cell cycle-coupled regulatory cascades in which RBPs bind to each other's transcripts and regulate transcript stability (although regulation of translation is one possibility that we did not investigate).
Although we cannot rule out the possibility that the AIR is mediated by certain factors released in a form of paracrine signalling, or by STAT3-regulated factors that compromise the stability of certain mRNA messages or their translation, a likely possibility is that STAT3 up-regulates a number of transcriptional repressors, which in turn suppress the expression of pro-inflammatory genes.
Even after this opening sequence ended, Benjamin remained the spirit overlooking "Spellbeamed," which shared a central concern of his work: the challenges and possibilities of translation.
In response, EE members, individually and jointly, need to focus on and make sense of the emerging possibilities this translation brings, rather than cling to their known firm and BU situations.
Collectively, these findings demonstrate that ultrasound-mediated gene delivery to endogenous mesenchymal progenitor cells can effectively improve ligament reconstruction in large animals, thereby addressing a major unmet orthopedic need and offering new possibilities for translation to the clinical setting.
Steiner made his reputation with books like "After Babel" (1975), a long and dazzling inquiry into the possibility of translation.
