54 56 Under certain conditions such as cell cycle arrest, miRNAs can alter their regulatory role from translational inhibition to upregulation of translation of target mRNAs.
microRNAs (miRNAs) are small RNAs that in general down-regulate the intracellular abundance and translation of target mRNAs.
MiRNAs play an essential role in the networks of gene regulation by inhibiting the translation of target mRNAs.
Importantly, due to their specific and modular behaviors, synthetic non-coding RNAs have been widely adopted to modulate transcription and translation of target genes.
MicroRNAs (miRNAs) are small noncoding RNAs that suppress the translation of target messenger RNA (mRNA) depending on the complementarity between miRNA and the 3′-untranslated region (3′-UTR) of target mRNA14.
Since their discovery, riboswitches have shown promise for the artificial control of transcription or translation of target genes, be it for industrial biotechnology, protein expression, metabolic engineering, antimicrobial target validation, or gene function discovery.
MicroRNAs (miRNAs) recruit the RNA-induced silencing complex (RISC) to repress the translation of target mRNAs.
In plant, however, microRNAs inhibit the translation of target mRNA through extensively complementarity to its targets (Wu, 2013).
Here we show that TNRC6A interacts with eIF4E2, a homologue of eIF4E that can bind to the cap but cannot interact with eIF4G to initiate translation, to inhibit the translation of target mRNAs.
Fmr1 knock-out mice exhibit exaggerated translation of target mRNAs at the synapse.
Binding leads to the degradation of target mRNAs and reduced translation of target proteins.
