It is essential to realize that both stoichiometry and stochasticity have critical roles to play in the translation of target interactions to biological effect.
Moreover, although hnRNP I enhances the translation of p27 (Kip1) through interaction with the 5′-untranslated region (5′-UTR) of p27 mRNAs, the interaction of UCA1 with hnRNP I suppresses the p27 protein level by competitive inhibition.
Das, S, Kenan, DJ, Bocskai, D, Keene, JD, and Dasgupta, A. "Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity". Journal of Virology 70, no. 3 (March 1996): 1624-1632.
HP directly regulates viral translation by repressing the translation of pgRNA through interaction with its 5′ Hε.
We show here that the liver-specific microRNA-122 (miR-122), a member of a class of small cellular RNAs that mediate post-transcriptional gene regulation usually by repressing the translation of mRNAs through interaction with their 3′-untranslated regions (UTRs), stimulates the translation of HCV.
Although it has been suggested that the exit tunnel is simply a convenient route of egress for the nascent chain, specific protein sequences serve to slow the rate of translation, suggesting some degree of interaction between the nascent peptide chain and the exit tunnel.
The indole moiety of these compounds is designed to mimic the translation stalling interaction of SecM W155 side-chain with the prokaryotic (Escherichia coli) ribosome A751 residue.
Is the observed inhibition of translation by the interaction of coronavirus S protein with eIF3f beneficial to the virus?
The process of translation initiation requires interaction of the initiator methionyl tRNA with eukaryotic initiation factor 2 (eIF2) bound to GTP to form a ternary complex.
For poliovirus IRES-mediated translation, the interaction of the cellular protein PCBP2 with a major secondary structure element (stem-loop IV) is required for gene expression.
