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In this scenario eEF1γ could contribute to the anchoring and translation of a set of mRNAs that are preferentially translated on cytoskeletal- or membrane-bound ribosomes, such as Vimentin mRNA.
Blocking the cap-dependent uORF translation up-regulates translation of a set of stress-responsive proteins58.
IGF2BP2 in turn binds to and controls the translation of a set of mRNAs, including c-myc, Sp1, and Igf1r.
The translation of a set B by point z= z 1,z 2), denoted as B z, becomes B_{z} = {b + z, | b in B }, quad forall z in E. (10).
The immediate early stress response is a mechanism in cells that encompasses the rapid transcription and translation of a set of genes coding for protein products that enable cells to adequately adapt to extra- or intracellular stress.
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How extrinsic cues are linked to the translation of a specific set of mRNAs is an important question.
Although overall translation is inhibited by eIF2α phosphorylation, the translation of a select set of mRNAs is increased under these conditions.
Some data suggest that erythroid progenitors respond to stress by selective changes in transcription, splicing or in the translation of a specific set of genes.
Nonetheless, we strongly suspect that inefficient translation of a limited set of eIF3e-associated mRNAs contributes to distinct cellular phenotypes found in eif3e mutants (see below).
Hence, it is possible that Sum2p and Sum3p act together to regulate the stability and translation of a similar set of mRNAs encoding check point proteins.
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