Exact(10)
The isoleucine to threonine substitution is known to impact post translation modifications such as phosphorylation.
A defining feature of α-syn is its amazing ability to self-associate into an array of soluble and insoluble high molecular mass species [13], and various post translation modifications of α-syn can occur (dopamine adduct formation [14], phosphorylation [15], proteolysis [16], and nitration [17]) that can alter its aggregation behavior and thus toxicity.
This suggests that other mechanisms which were not screened here or post translation modifications may be involved in the effects observed.
Peptide recognition modules (PRMs) are an important subclass of modular protein domains that specifically recognize short linear peptides to mediate various post translation modifications [ 4].
It is plausible that PGAM5 post translation modifications are more important for mediating its biological role than its abundance or up-regulation does not have as pronounced biological effects as its knockdown.
Further simulations are required to explore the influence of post translation modifications on the PMF of the channel not only for small inorganic ions but also for large permeant molecules.
Similar(50)
The second limitation affects all gene array studies and derives from the fact that one gene can encode multiple spliced forms of transcripts, and further, the translated proteins undergo various post-translation modifications.
Alternative splicing and post-translation modifications represent further layers for modulating this complex molecular network.
Kumar, A., Kashyap, M., Bhavesh, N. S., Yogavel, M. & Sharma, A. Structural delineation of histone post-translation modifications in histone-nucleosome assembly protein complex.
The data were interrogated for variable post-translation modifications on lysine with masses of 72.0211 Da (trapped carbamate) and 28.0313 Da (O-ethylation on glutamate and aspartate side chains).
In order to get the most meaningful and comprehensive results from protein library screens, it is essential to have library proteins in their native conformation with proper post-translation modifications.
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