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Amis et al. (1991) reported that the anterior tibial translation increased by approximately 140% after removal of the ACL on application of 150 N of anterior tibial load at 20° of flexion.
When the frequency of the platform translation increased to 0.6Hz, with EC, the general picture was similar to the above, but in older subjects vision was no longer able to counteract the imposed head displacement.
MicroRNAs regulate gene expression through decreased translation, increased degradation of the target message, or both [39].
In contrast to nPTB and ROD1, PTB1 translation increased with mRNA concentration and no decrease in yield of full-length product was observed.
Enhanced Nrf2 translation was observed when rat cardiomyocytes were treated with hydrogen peroxide although the detailed mechanism of how the Nrf2 translation increased remains unknown [31].
The activation of the UPR results in an overall decrease in translation, increased protein degradation and increased levels of ER chaperones, including GRP78/Bip [8], which consequently increases the protein folding capacity of the ER.
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In particular, attention to capacity building and knowledge translation increases as the programs mature over time.
This short-term adaptive system is necessary to maintain balance in the protein folding machinery by activating protein modification and gene expression programs designed to inhibit protein translation, increase the production of protein chaperones, and stimulate protein degradation.
We also want to emphasize that both the reduction and the back-translation increases the interpretability and biochemical understanding of the model.
This suggests that siRNA-mediated knockdown of PTB reduced the proposed PTB-mediated inhibition in FCV translation resulting in increased translation from the transfected sgRNA.
Deficiency of modified nucleosides can, therefore, lead to reduced translation efficiency and increased translation errors, which will affect gene expression regulation and cell metabolism [ 9].
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